| Title | The pharmacokinetics of methadone following co-administration with a lamivudine/zidovudine combination tablet in opiate-dependent subjects. |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Rainey, Petrie M., Gerald H. Friedland, Jerry W. Snidow, Elinore F. McCance-Katz, Susan M. Mitchell, Laurie Andrews, Barbara Lane, and Peter Jatlow |
| Journal | The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions |
| Volume | 11 |
| Issue | 1 |
| Pagination | 66-74 |
| Date Published | 2002 Winter |
| ISSN | 1055-0496 |
| Keywords | Adolescent, Adult, Anti-HIV Agents, Drug Combinations, Female, HIV Seropositivity, Humans, Lamivudine, Male, Methadone, Middle Aged, Narcotics, Opioid-Related Disorders, Zidovudine |
| Abstract | Methadone pharmacokinetics were determined in an open-label, within subject study in 16 methadone-maintained, non-HIV-infected subjects prior to and following administration of one lamivudine 150-mg/zidovudine 300-mg combination tablet to determine whether this antiretroviral therapy alters methadone serum concentrations. No significant differences in the mean area under the serum concentration-time curve (AUC(0-24h); 8,753 +/- 4,280 vs. 8,641 +/- 4,431 microg-h/L),oralclearance(CL/F;9.9 +/- 4.9vs. 10.3 +/- 5.5 L/h),oral volume of distribution (Vd/F; 647 +/- 465 vs. 481 +/- 305 L), maximum serum concentration (Cmax; 514 +/- 223 vs. 5,510 +/- 237 microg/L), or terminal elimination half-life (t 1/2; 55.3 +/- 61.0 vs. 35.0 +/- 17.5 h) were detected. These results suggest that methadone dose change is not likely to be necessary for patients treated with lamivudine/zidovudine combination pharmacotherapy. |
| Alternate Journal | Am J Addict |
