| Title | A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Simoni, Jane M., Wei-Ti Chen, David Huh, Karen I. Fredriksen-Goldsen, Cynthia Pearson, Hongxin Zhao, Cheng-Shi Shiu, Xin Wang, and Fujie Zhang |
| Journal | AIDS and behavior |
| Volume | 15 |
| Issue | 5 |
| Pagination | 919-29 |
| Date Published | 2011 Jul |
| ISSN | 1573-3254 |
| Keywords | Adult, Anti-HIV Agents, CD4 Lymphocyte Count, China, Counseling, Cross-Sectional Studies, Drug Monitoring, Electronics, Medical, Female, HIV Infections, HIV-1, Humans, Intervention Studies, Male, Medication Adherence, Middle Aged, Nurses, Outpatients, RNA, Viral, Treatment Outcome, Viral Load, Young Adult |
| Abstract | We evaluated a nurse-delivered adherence intervention in a preliminary randomized controlled trial among 70 HIV-positive outpatients initiating antiretroviral therapy (ART) in Beijing, China. In both arms, participants received a 30-min educational session, a pillbox, and a referral to a peer support group. In the enhanced arm, participants could choose an electronic reminder device, three sessions of counseling either alone or with a treatment adherence partner, or both reminder and counseling. Survey assessments and blood draws occurred at baseline, post-intervention (13 weeks), and follow-up (25 weeks). Primary outcomes were 7-day and 30-day adherence assessed by self-report and electronic drug monitoring (EDM), and secondary outcomes were HIV-1 RNA viral load and CD4 count. The intervention was feasible and well received. It led to some improvement in self-reported and EDM-assessed adherence but not the biological outcomes. Providing counseling and facilitating the use of electronic reminders to patients initiating ART merits further investigation as a culturally viable means of promoting adherence in China. |
| DOI | 10.1007/s11606-010-1323-z |
| Alternate Journal | AIDS Behav |
