| Title | Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Schottenfeld, Richard S., Marek C. Chawarski, Joseph F. Cubells, Tony P. George, Jaakko Lappalainen, and Thomas R. Kosten |
| Journal | Drug and alcohol dependence |
| Date Published | 2013 Dec 25 |
| ISSN | 1879-0046 |
| Abstract | Disulfiram may be efficacious for treating cocaine dependence or abuse, possibly through inhibiting dopamine β-hydroxylase (DβH). Consequently, this randomized, placebo-controlled clinical trial of disulfiram during buprenorphine maintenance treatment evaluated the study hypothesis that disulfiram is superior to placebo and explored whether disulfiram response is greatest for participants with a single nucleotide polymorphism coding for genetically low DβH (T-allele carriers). |
| DOI | 10.1016/j.drugalcdep.2013.12.007 |
| Alternate Journal | Drug Alcohol Depend |
