| Title | The rate of epidemiological and virological changes during the transition from nascent to concentrated HIV epidemic stage in the former Soviet Union countries. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Nabatov, Alexey A., Alexey E. Masharsky, Sergei V. Verevochkin, Alexander V. Emelyanov, Vladimir V. Lukashov, Robert Heimer, Robert W. Ryder, Jaap Goudsmit, and Andrei P. Kozlov |
| Journal | AIDS research and human retroviruses |
| Volume | 23 |
| Issue | 2 |
| Pagination | 183-92 |
| Date Published | 2007 Feb |
| ISSN | 0889-2229 |
| Keywords | Acquired Immunodeficiency Syndrome, Disease Outbreaks, Female, Genetic Variation, HIV Seropositivity, HIV Seroprevalence, HIV-1, Humans, Male, Molecular Sequence Data, Phylogeny, Risk Factors, Russia, Substance Abuse, Intravenous |
| Abstract | The rate of processes accompanying the transition of the HIV-1 epidemic from nascent stage to concentrated one in the Former Soviet Union (FSU) during intravenous drug user (IDU)-associated HIV infection outbreaks in 1994-1999 has not been analyzed. To define the rates, we studied susceptible populations and circulating viruses before, during, and after the outbreaks. Our findings included the following: (1) the pattern of high HIV-1 genetic diversity characteristic of the nascent epidemic changed to a concentrated one within 1 year in St. Petersburg and in Moscow; (2) different FSU regions were at different stages of the HIV-1 epidemic in 1994-1996; (3) the change of serotypic patterns characteristic of different stages of the HIV/AIDS epidemic for the non-IDU risk group occurred within 1 year in Moscow, suggesting an extremely high rate of IDU-associated epidemic pattern distributions in regions and susceptible populations in the FSU. |
| DOI | 10.1111/j.1360-0443.2010.03149.x |
| Alternate Journal | AIDS Res. Hum. Retroviruses |
