Title | The role of substance abuse in HIV disease progression: reconciling differences from laboratory and epidemiologic investigations. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Kapadia, Farzana, David Vlahov, Robert M. Donahoe, and Gerald Friedland |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Volume | 41 |
Issue | 7 |
Pagination | 1027-34 |
Date Published | 2005 Oct 1 |
ISSN | 1537-6591 |
Keywords | Animals, Disease Progression, HIV Infections, Humans, Substance-Related Disorders |
Abstract | From the onset of the HIV/AIDS epidemic, the use of licit and illicit drugs has been investigated for its potential impact on HIV disease progression. Findings from a large number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease progression; however, epidemiological studies have shown mixed results. This article presents a review of findings from both laboratory-based and epidemiologic investigations. In addition, we provide a careful evaluation of methodological strengths and limitations inherent to both study designs in order to provide a more nuanced understanding of how these findings may complement one another. |
DOI | 10.3109/00952990.2011.568081 |
Alternate Journal | Clin. Infect. Dis. |