Yale University

The role of substance abuse in HIV disease progression: reconciling differences from laboratory and epidemiologic investigations.

TitleThe role of substance abuse in HIV disease progression: reconciling differences from laboratory and epidemiologic investigations.
Publication TypeJournal Article
Year of Publication2005
AuthorsKapadia, Farzana, David Vlahov, Robert M. Donahoe, and Gerald Friedland
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume41
Issue7
Pagination1027-34
Date Published2005 Oct 1
ISSN1537-6591
KeywordsAnimals, Disease Progression, HIV Infections, Humans, Substance-Related Disorders
AbstractFrom the onset of the HIV/AIDS epidemic, the use of licit and illicit drugs has been investigated for its potential impact on HIV disease progression. Findings from a large number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease progression; however, epidemiological studies have shown mixed results. This article presents a review of findings from both laboratory-based and epidemiologic investigations. In addition, we provide a careful evaluation of methodological strengths and limitations inherent to both study designs in order to provide a more nuanced understanding of how these findings may complement one another.
DOI10.3109/00952990.2011.568081
Alternate JournalClin. Infect. Dis.

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