| Title | Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Sterne, Jonathan A. C., Margaret May, Dominique Costagliola, Frank de Wolf, Andrew N. Phillips, Ross Harris, Michele Jönsson Funk, Ronald B. Geskus, John Gill, François Dabis, Jose M. Miró, Amy C. Justice, Bruno Ledergerber, Gerd Fätkenheuer, Robert S. Hogg, Antonella d'Arminio Monforte, Michael Saag, Colette Smith, Schlomo Staszewski, Matthias Egger, and Stephen R. Cole |
| Corporate Authors | When To Start Consortium |
| Journal | Lancet |
| Volume | 373 |
| Issue | 9672 |
| Pagination | 1352-63 |
| Date Published | 2009 Apr 18 |
| ISSN | 1474-547X |
| Keywords | Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Cohort Studies, Disease Progression, Drug Administration Schedule, Europe, Female, HIV Infections, HIV-1, Humans, Kaplan-Meier Estimate, Male, Middle Aged, North America, Patient Selection, Practice Guidelines as Topic, Proportional Hazards Models, Sensitivity and Specificity, Time Factors, Treatment Outcome |
| Abstract | The CD4 cell count at which combination antiretroviral therapy should be started is a central, unresolved issue in the care of HIV-1-infected patients. In the absence of randomised trials, we examined this question in prospective cohort studies. |
| DOI | 10.1016/S0140-6736(09)60612-7 |
| Alternate Journal | Lancet |
