| Title | Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Bruce, Douglas R., David E. Moody, Wenfang B. Fang, Diane Chodkowski, Laurie Andrews, and Gerald H. Friedland |
| Journal | The American journal of drug and alcohol abuse |
| Volume | 37 |
| Issue | 4 |
| Pagination | 224-8 |
| Date Published | 2011 Jul |
| ISSN | 1097-9891 |
| Keywords | Adult, Buprenorphine, Drug Interactions, Female, HIV Seronegativity, Humans, Male, Metabolic Detoxication, Drug, Middle Aged, Naloxone, Narcotic Antagonists, Opioid-Related Disorders, Pyridines, Pyrones, Ritonavir |
| Abstract | Previous reports on the pharmacokinetic of tipranavir (TPV) and buprenorphine (BUP)/ naloxone found that coadministration resulted in an 80% reduction in the area under the curve AUC of the primary BUP metabolite, norBUP, without any pharmacodynamic consequences. This study was conducted to characterize how tipranivir/ritonavir effects the glucuronide metabolites of BUP and may explain the reduction in the norBUP. |
| DOI | 10.1097/QAI.0b013e3181fbc94f |
| Alternate Journal | Am J Drug Alcohol Abuse |
