| Title | The association between cocaine use and treatment outcomes in patients receiving office-based buprenorphine/naloxone for the treatment of opioid dependence. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Sullivan, Lynn E., Brent A. Moore, Patrick G. O'Connor, Declan T. Barry, Marek C. Chawarski, Richard S. Schottenfeld, and David A. Fiellin |
| Journal | The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions |
| Volume | 19 |
| Issue | 1 |
| Pagination | 53-8 |
| Date Published | 2010 Jan-Feb |
| ISSN | 1521-0391 |
| Keywords | Adult, Buprenorphine, Cocaine, Drug Therapy, Combination, Female, Humans, Male, Medication Adherence, Naloxone, Narcotic Antagonists, Office Visits, Opioid-Related Disorders, Street Drugs, Treatment Outcome |
| Abstract | Cocaine use in patients receiving methadone is associated with worse treatment outcomes. The association between cocaine use and office-based buprenorphine/naloxone treatment outcomes is not known. We evaluated the association between baseline and in-treatment cocaine use, treatment retention, and urine toxicology results in 162 patients enrolled in a 24-week trial of primary care office-based buprenorphine/naloxone maintenance. Patients with baseline cocaine metabolite-negative urine toxicology tests compared with those with cocaine metabolite-positive tests had more mean weeks of treatment retention (18.3 vs. 15.8, p = .04), a greater percentage completed 24 weeks of treatment (50% vs. 33%, p = .04) and had a greater percentage of opioid-negative urines (47% vs. 34%, p = .02). Patients with in-treatment cocaine metabolite-negative urine toxicology tests compared with cocaine metabolite-positive patients had more mean weeks of treatment retention (19.0 vs. 16.5, p = .003), a greater percentage completed 24 weeks of treatment (60% vs. 30%, p < .001), and had a greater percentage of opioid-negative urines (51% vs. 35%, p = .001). We conclude that both baseline and in-treatment cocaine use is associated with worse treatment outcomes in patients receiving office-based buprenorphine/naloxone and may benefit from targeted interventions. |
| DOI | 10.1111/j.1475-6773.2011.01335.x |
| Alternate Journal | Am J Addict |
