Yale University

Association betweenTLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users.

TitleAssociation betweenTLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users.
Publication TypeJournal Article
Year of Publication2013
AuthorsHuik, Kristi, Radko Avi, Merit Pauskar, Eveli Kallas, Ene-Ly Jõgeda, Tõnis Karki, Kristina Marsh, Don Des Jarlais, Anneli Uusküla, and Irja Lutsar
JournalInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Date Published2013 Aug 17
ISSN1567-7257
AbstractTLR3 recognizes dsRNA and triggers immune responses against RNA and DNA viruses. A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. We investigated Caucasian intravenous drug users (IDUs) and blood donors in order to evaluate the associations between TLR3 genotypes and susceptibility to HIV infection.
DOI10.1111/milq.12017
Alternate JournalInfect. Genet. Evol.

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