Yale University

Characteristics of HIV-1-associated Kaposi's sarcoma among women and men in South Africa.

TitleCharacteristics of HIV-1-associated Kaposi's sarcoma among women and men in South Africa.
Publication TypeJournal Article
Year of Publication2008
AuthorsMosam, A., H. P. Hurkchand, E. Cassol, T. Page, S. Cassol, U. Bodasing, J. Aboobaker, H. Dawood, G. H. Friedland, and H. M. Coovadia
JournalInternational journal of STD & AIDS
Date Published2008 Jun
KeywordsAdult, AIDS-Related Opportunistic Infections, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, HIV Infections, HIV Seropositivity, HIV-1, Humans, Male, Sarcoma, Kaposi, South Africa
AbstractDespite the increase of HIV-1-associated Kaposi's sarcoma (KS), little is known about HIV-associated KS in the African setting, particularly among women. A descriptive study of the demographic, clinical, immunological and virological features of AIDS-associated KS from KwaZulu-Natal, South Africa was undertaken. Consecutively, recruited patients were clinically staged; CD4/CD8 cell counts, HIV-1 viral loads and clinical parameters were evaluated. Of the 152 patients (77 male and 75 female) 99% were black. Females were significantly younger (P = 0.02) and had poorer disease prognosis (odds ratio [OR] = 2.7, 95% confidence interval [CI] = 1.4-5.4, P = 0.003) and were more likely to have extensive cutaneous KS when compared with males (OR = 3.1, 95% CI = 1.4-6.7, P = 0.003). One-third of patients had coexisting HIV-related disease, most commonly tuberculosis, and these were more frequent in females (56.7 vs. 43.3%). In conclusion, HIV-associated KS in South Africans has an equal female-to-male ratio. Females are younger and have more severe disease than males.
Alternate JournalInt J STD AIDS

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