| Title | Do benefits of earlier antiretroviral treatment initiation outweigh harms for individuals at risk for poor adherence? |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Braithwaite, Scott R., Mark S. Roberts, Matthew Bidwell Goetz, Cynthia L. Gibert, Maria C. Rodriguez-Barradas, Kimberly Nucifora, and Amy C. Justice |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Volume | 48 |
| Issue | 6 |
| Pagination | 822-6 |
| Date Published | 2009 Mar 15 |
| ISSN | 1537-6591 |
| Keywords | Adult, Antiviral Agents, Computer Simulation, HIV Infections, Humans, Life Expectancy, Medication Adherence, Middle Aged, Time Factors, Treatment Outcome |
| Abstract | Clinicians may defer antiretroviral treatment for patients with suboptimal adherence. We used a validated computer simulation of HIV disease progression to compare alternative treatment thresholds for patients with suboptimal adherence. Earlier treatment increased life expectancy across a wide adherence range (50%-100% of doses taken). Delaying treatment for patients with suboptimal adherence may not always be appropriate. |
| DOI | 10.1086/528859 |
| Alternate Journal | Clin. Infect. Dis. |
