Yale University

FIB-4 index is associated with hepatocellular carcinoma risk in HIV-infected patients.

TitleFIB-4 index is associated with hepatocellular carcinoma risk in HIV-infected patients.
Publication TypeJournal Article
Year of Publication2011
AuthorsPark, Lesley S., Janet P. Tate, Amy C. Justice, Vincent Lo Re, Joseph K. Lim, Norbert Bräu, Sheldon T. Brown, Adeel A. Butt, Cynthia Gibert, Matthew Bidwell Goetz, David Rimland, Maria C. Rodriguez-Barradas, and Robert Dubrow
JournalCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Date Published2011 Dec
KeywordsAdult, Age Factors, Aged, Alanine Transaminase, Aspartate Aminotransferases, Biological Markers, Carcinoma, Hepatocellular, Cohort Studies, Female, HIV Infections, Humans, Liver Function Tests, Liver Neoplasms, Male, Middle Aged, Platelet Count, Risk Factors
AbstractChronic inflammation caused by hepatitis B virus infection, hepatitis C virus infection, and/or heavy alcohol use can lead to fibrosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). FIB-4 is an index score calculated from platelet count, alanine transaminase, aspartate transaminase, and age that predicts fibrosis and cirrhosis. We hypothesized that high FIB-4 would be associated with development of HCC in HIV-infected persons, who are at high risk due to high prevalence of viral hepatitis and alcohol consumption, and possibly due to HIV infection itself.
Alternate JournalCancer Epidemiol. Biomarkers Prev.

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