Yale University

HIV drug resistance and HIV transmission risk behaviors among active injection drug users.

TitleHIV drug resistance and HIV transmission risk behaviors among active injection drug users.
Publication TypeJournal Article
Year of Publication2005
AuthorsKozal, Michael J., Rivet K. Amico, Jennifer Chiarella, Deborah Cornman, William Fisher, Jeffrey Fisher, and Gerald Friedland
JournalJournal of acquired immune deficiency syndromes (1999)
Date Published2005 Sep 1
KeywordsAnti-HIV Agents, Cross-Sectional Studies, Disease Transmission, Infectious, Drug Resistance, Female, HIV, HIV Infections, Humans, Male, Needle Sharing, Retrospective Studies, Risk-Taking, Substance Abuse, Intravenous
AbstractHIV(+) injection drug users in clinical care may harbor and transmit drug-resistant HIV. We performed a retrospective study of HIV drug resistance and risk behavior among HIV(+) injection drug users in care to determine the number of needle-sharing events that involved and the proportion of sharing partners exposed to drug-resistant HIV. Among 180 HIV injection drug users, 55 (31%) reported injecting drugs in the previous month, and 22 of these (40%) shared needles and/or works 148 times with 296 partners, of whom 271 (92%) were thought to be HIV(-) or status unknown. Further, 55 (31%) drug users harbored resistant HIV, including 5 (3% of total) who also shared needles and/or works a total of 27 times with 44 partners (18% of all sharing events and 15% of all exposed partners). A small proportion of injection drug users receiving clinical care engage in injection risk behavior and carry resistant HIV; however, because of multiple partners and needle-sharing events, they expose a substantial number of individuals to drug-resistant HIV. Strategies to reduce injection drug use risk behaviors among patients in clinical care are needed to reduce the transmission of sensitive and resistant HIV.
Alternate JournalJ. Acquir. Immune Defic. Syndr.

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