| Title | Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV+, treatment-naïve U.S. veterans. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Nelson, Kristin N., Qin Hui, David Rimland, Ke Xu, Matthew S. Freiberg, Amy C. Justice, Vincent C. Marconi, and Yan V. Sun |
| Journal | AIDS (London, England) |
| Date Published | 2016 Dec 05 |
| ISSN | 1473-5571 |
| Abstract | HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNAm age, an aging marker involving multiple age-related CpG sites, among antiretroviral treatment (ART) naïve HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study (VACS). |
| Alternate Journal | AIDS |
