| Title | Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid-free rabbit anti-human thymocyte globulin. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Talukdar, Anjan J., Chethan Ashokkumar, Patrick Wilson, Ankit Gupta, Qing Sun, Linda Boig, Kareem Abu-Elmagd, George Mazariegos, Michael Green, and Rakesh Sindhi |
| Journal | Pediatric transplantation |
| Volume | 13 |
| Issue | 3 |
| Pagination | 353-9 |
| Date Published | 2009 May |
| ISSN | 1399-3046 |
| Keywords | Adolescent, Antilymphocyte Serum, CD4-Positive T-Lymphocytes, Child, Child, Preschool, Female, Graft Survival, Herpesvirus 4, Human, Humans, Immunosuppressive Agents, Infant, Intestine, Small, Killer Cells, Natural, Lymphocyte Subsets, Male, Organ Transplantation, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Tacrolimus, Viral Load, Young Adult |
| Abstract | Multiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid-free Tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post-transplant year. During the period at risk for rejection, NK and T-cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at-risk recipients. Rejection-prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence. |
| DOI | 10.1086/528859 |
| Alternate Journal | Pediatr Transplant |
