Yale University

Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid-free rabbit anti-human thymocyte globulin.

TitleLymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid-free rabbit anti-human thymocyte globulin.
Publication TypeJournal Article
Year of Publication2009
AuthorsTalukdar, Anjan J., Chethan Ashokkumar, Patrick Wilson, Ankit Gupta, Qing Sun, Linda Boig, Kareem Abu-Elmagd, George Mazariegos, Michael Green, and Rakesh Sindhi
JournalPediatric transplantation
Volume13
Issue3
Pagination353-9
Date Published2009 May
ISSN1399-3046
KeywordsAdolescent, Antilymphocyte Serum, CD4-Positive T-Lymphocytes, Child, Child, Preschool, Female, Graft Survival, Herpesvirus 4, Human, Humans, Immunosuppressive Agents, Infant, Intestine, Small, Killer Cells, Natural, Lymphocyte Subsets, Male, Organ Transplantation, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Tacrolimus, Viral Load, Young Adult
AbstractMultiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid-free Tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post-transplant year. During the period at risk for rejection, NK and T-cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at-risk recipients. Rejection-prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence.
DOI10.1086/528859
Alternate JournalPediatr Transplant

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