| Title | Psychosocial Predictors of Non-Adherence and Treatment Failure in a Large Scale Multi-National Trial of Antiretroviral Therapy for HIV: Data from the ACTG A5175/PEARLS Trial. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Safren, Steven A., Katie B. Biello, Laura Smeaton, Matthew J. Mimiaga, Ann Walawander, Javier R. Lama, Aadia Rana, Mulinda Nyirenda, Virginia M. Kayoyo, Wadzanai Samaneka, Anjali Joglekar, David Celentano, Ana Martinez, Jocelyn E. Remmert, Aspara Nair, Umesh G. Lalloo, Nagalingeswaran Kumarasamy, James Hakim, and Thomas B. Campbell |
| Corporate Authors | PEARLS(ACTG A5175) Study Team |
| Journal | PloS one |
| Volume | 9 |
| Issue | 8 |
| Pagination | e104178 |
| Date Published | 2014 |
| ISSN | 1932-6203 |
| Abstract | PEARLS, a large scale trial of antiretroviral therapy (ART) for HIV (n = 1,571, 9 countries, 4 continents), found that a once-daily protease inhibitor (PI) based regimen (ATV+DDI+FTC), but not a once-daily non-nucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) regimen (EFV+FTC/TDF), had inferior efficacy compared to a standard of care twice-daily NNRTI/NRTI regimen (EFV+3TC/ZDV). The present study examined non-adherence in PEARLS. |
| DOI | 10.1371/journal.pone.0104178 |
| Alternate Journal | PLoS ONE |
